abstract：:Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospect...

journal_title：European journal of endocrinology

authors： Bonneville F,Rivière LD,Petersenn S,Bevan J,Houchard A,Sert C,Caron PJ,PRIMARYS Study group.

更新日期：2018-12-01 00:00:00

abstract：:Context Abnormalities in the hypothalamo-pituitary-gonadal axis have long been reported in Noonan syndrome (NS) males with only few data available in prepubertal children. Objective The aim of this study was to describe the gonadal function of NS males from childhood to adulthood. Design It is a retrospective chart re...

journal_title：European journal of endocrinology

authors： Moniez S,Pienkowski C,Lepage B,Hamdi S,Daudin M,Oliver I,Jouret B,Cartault A,Diene G,Verloes A,Cavé H,Salles JP,Tauber M,Yart A,Edouard T

更新日期：2018-12-01 00:00:00

abstract：Objective:Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas; however, their prognosis differs significantly upon their proliferative state, which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expressi...

journal_title：European journal of endocrinology

authors： Grolmusz VK,Kövesdi A,Borks K,Igaz P,Patócs A

更新日期：2018-10-01 00:00:00

abstract：:The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the LH receptor ...

journal_title：European journal of endocrinology

authors： Huhtaniemi I

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Epigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET) development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene silencing is a well-established oncogenic mechanism that is potentially reversible and therefore an interesting therapeutic target. Multiple endocrine neo...

journal_title：European journal of endocrinology

authors： Conemans EB,Lodewijk L,Moelans CB,Offerhaus GJA,Pieterman CRC,Morsink FH,Dekkers OM,de Herder WW,Hermus AR,van der Horst-Schrivers AN,Drent ML,Bisschop PH,Havekes B,Brosens LAA,Dreijerink KMA,Borel Rinkes IHM,Timmers HTM

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:According to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim o...

journal_title：European journal of endocrinology

authors： Albano D,Bertagna F,Bonacina M,Durmo R,Cerudelli E,Gazzilli M,Panarotto MB,Formenti AM,Mazziotti G,Giustina A,Giubbini R

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:ATL1103 is a second-generation antisense oligomer targeting the human growth hormone (GH) receptor. This phase 2 randomised, open-label, parallel-group study assessed the potential of ATL1103 as a treatment for acromegaly. DESIGN:Twenty-six patients with active acromegaly (IGF-I >130% upper limit of normal) ...

journal_title：European journal of endocrinology

authors： Trainer PJ,Newell-Price JDC,Ayuk J,Aylwin SJB,Rees A,Drake W,Chanson P,Brue T,Webb SM,Fajardo C,Aller J,McCormack AI,Torpy DJ,Tachas G,Atley L,Ryder D,Bidlingmaier M

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative genes has been limited. DESIGN AND METHODS:One hundred ten patients with primary CH w...

journal_title：European journal of endocrinology

authors： Sun F,Zhang JX,Yang CY,Gao GQ,Zhu WB,Han B,Zhang LL,Wan YY,Ye XP,Ma YR,Zhang MM,Yang L,Zhang QY,Liu W,Guo CC,Chen G,Zhao SX,Song KY,Song HD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:A substantial proportion of all pheochromocytomas is currently detected during the evaluation of an adrenal incidentaloma. Recently, it has been suggested that biochemical testing to rule out pheochromocytoma is unnecessary in case of an adrenal incidentaloma with an unenhanced attenuation value ≤10 Hounsfie...

journal_title：European journal of endocrinology

authors： Buitenwerf E,Korteweg T,Visser A,Haag CMSC,Feelders RA,Timmers HJLM,Canu L,Haak HR,Bisschop PHLT,Eekhoff EMW,Corssmit EPM,Krak NC,Rasenberg E,van den Bergh J,Stoker J,Greuter MJW,Dullaart RPF,Links TP,Kerstens MN

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Somapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily Norditropin®. Local tolerability and treatment satisfaction were also assessed. DESIGN:26-week randomized, con...

journal_title：European journal of endocrinology

authors： Johannsson G,Feldt-Rasmussen U,Håkonsson IH,Biering H,Rodien P,Tahara S,Toogood A,Rasmussen MH,REAL 2 Study Group.

更新日期：2018-05-01 00:00:00

abstract：:Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-gener...

journal_title：European journal of endocrinology

authors： Kasuki L,Wildemberg LE,Gadelha MR

更新日期：2018-03-01 00:00:00

abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

journal_title：European journal of endocrinology

authors： Canalis E

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Biallelic TSHR mutations cause congenital hypothyroidism (CH). Serum TSH levels of monoallelic mutation carriers range from normal to mildly elevated, and thus the size of its effect remains unclear. The objectives were to examine the association between monoallelic TSHR mutations and positivity at newborn sc...

journal_title：European journal of endocrinology

authors： Abe K,Narumi S,Suwanai AS,Adachi M,Muroya K,Asakura Y,Nagasaki K,Abe T,Hasegawa T

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Platinum-based chemotherapy (PBC) is the most effective cytotoxic treatment for advanced adrenocortical carcinoma (ACC). Excision repair cross complementing group 1 (ERCC1) plays a critical role in the repair of platinum-induced DNA damage. Two studies investigating the role of ERCC1 immunostaining as a predi...

journal_title：European journal of endocrinology

authors： Laufs V,Altieri B,Sbiera S,Kircher S,Steinhauer S,Beuschlein F,Quinkler M,Willenberg HS,Rosenwald A,Fassnacht M,Ronchi CL

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Patients with craniopharyngioma are at an increased risk for cardio- and cerebrovascular mortality. The metabolic syndrome (MetS) is an important cardiometabolic risk factor, but barely studied in patients with craniopharyngioma. We aimed to investigate the prevalence of and risk factors for the MetS and its ...

journal_title：European journal of endocrinology

authors： Wijnen M,Olsson DS,van den Heuvel-Eibrink MM,Hammarstrand C,Janssen JAMJL,van der Lely AJ,Johannsson G,Neggers SJCMM

更新日期：2018-01-01 00:00:00

abstract：CONTEXT:Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA). OBJECTIVE:To elucidate both cortical and trabecular bone microarchi...

journal_title：European journal of endocrinology

authors： Silva PPB,Amlashi FG,Yu EW,Pulaski-Liebert KJ,Gerweck AV,Fazeli PK,Lawson E,Nachtigall LB,Biller BMK,Miller KK,Klibanski A,Bouxsein M,Tritos NA

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. DESIGN:Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. METHO...

journal_title：European journal of endocrinology

authors： Salcuni AS,Carnevale V,Battista C,Palmieri S,Eller-Vainicher C,Guarnieri V,Pugliese F,Guglielmi G,Desina G,Minisola S,Chiodini I,Scillitani A

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Flushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying orga...

journal_title：European journal of endocrinology

authors： Huguet I,Grossman A

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:The cardiovascular system is a known target for thyroid hormone. Early-life cardiovascular alterations may lead to a higher risk of cardiovascular disease in adulthood. Little is known about the effects of thyroid hormone on cardiovascular function during childhood, including the role of body composition in t...

journal_title：European journal of endocrinology

authors： Barjaktarovic M,Korevaar TIM,Gaillard R,de Rijke YB,Visser TJ,Jaddoe VWV,Peeters RP

更新日期：2017-10-01 00:00:00

abstract：:Thyrotropin (TSH)-secreting adenomas (TSHomas) are the rarest form of pituitary adenomas, and most endocrinologists will see few cases in a lifetime, if any. In most cases, the diagnostic approach is complicated and cases may be referred after being presented as a syndrome of inappropriate TSH secretion or as a pituit...

journal_title：European journal of endocrinology

authors： Tjörnstrand A,Nyström HF

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Thyroid hormone (TH) transporters are expressed in thyrocytes and most play a role in TH release. We asked whether expression of the monocarboxylate transporter 8 (MCT8) and the L-type amino acid transporters LAT2 and LAT4 is changed with thyrocyte dedifferentiation and in hyperfunctioning thyroid tissues. D...

journal_title：European journal of endocrinology

authors： Badziong J,Ting S,Synoracki S,Tiedje V,Brix K,Brabant G,Moeller LC,Schmid KW,Fuhrer D,Zwanziger D

更新日期：2017-09-01 00:00:00

abstract：CONTEXT:Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) and head and neck paragangliomas (HNPGLs), but utility for screening beyond that achieved using standard measurements of normetanephrine and...

journal_title：European journal of endocrinology

authors： Rao D,Peitzsch M,Prejbisz A,Hanus K,Fassnacht M,Beuschlein F,Brugger C,Fliedner S,Langton K,Pamporaki C,Gudziol V,Stell A,Januszewicz A,Timmers HJLM,Lenders JWM,Eisenhofer G

更新日期：2017-08-01 00:00:00

abstract：:Glucose is the main substrate utilized by the brain and as such multiple regulatory mechanisms exist to maintain glucose concentrations. When these mechanisms fail or are defective, hypoglycemia ensues. Due to these robust mechanisms, hypoglycemia is uncommon and usually occurs in the setting of the treatment of diabe...

journal_title：European journal of endocrinology

authors： Kittah NE,Vella A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is oft...

journal_title：European journal of endocrinology

authors： Yance VRV,Marcondes JAM,Rocha MP,Barcellos CRG,Dantas WS,Avila AFA,Baroni RH,Carvalho FM,Hayashida SAY,Mendonca BB,Domenice S

更新日期：2017-07-01 00:00:00

abstract：:Tall stature is defined as a height of more than 2 standard deviations (s.d.) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitut...

journal_title：European journal of endocrinology

authors： Albuquerque EVA,Scalco RC,Jorge AAL

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To evaluate which tests are performed to diagnose hypercortisolism in patients included in the European Registry on Cushing's syndrome (ERCUSYN), and to examine if their use differs from the current guidelines. PATIENTS AND METHODS:We analyzed data on the diagnostic tests performed in 1341 patients with Cush...

journal_title：European journal of endocrinology

authors： Valassi E,Franz H,Brue T,Feelders RA,Netea-Maier R,Tsagarakis S,Webb SM,Yaneva M,Reincke M,Droste M,Komerdus I,Maiter D,Kastelan D,Chanson P,Pfeifer M,Strasburger CJ,Tóth M,Chabre O,Tabarin A,Krsek M,Fajardo C,B

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Estimates of the prevalence of hypothyroidism in unselected populations date from the late 1990s. We present an update on the prevalence and incidence of overt hypothyroidism in Piedmont, northwest Italy and examine the association between hypothyroidism and multiple chronic comorbidities. DESIGN AND METHODS...

journal_title：European journal of endocrinology

authors： Giorda CB,Carnà P,Romeo F,Costa G,Tartaglino B,Gnavi R

更新日期：2017-05-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions, such as low energy, increasing energy production and reducing energy waste. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, wi...

journal_title：European journal of endocrinology

authors： López M

更新日期：2017-05-01 00:00:00

abstract：CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...

journal_title：European journal of endocrinology

authors： Maione L,Brue T,Beckers A,Delemer B,Petrossians P,Borson-Chazot F,Chabre O,François P,Bertherat J,Cortet-Rudelli C,Chanson P,French Acromegaly Registry Group.

更新日期：2017-05-01 00:00:00

abstract：:Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-e...

journal_title：European journal of endocrinology

authors： Chemaitilly W,Cohen LE

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. OBJECTIVE:To identify predictors of the PEGV dose requ...

journal_title：European journal of endocrinology

authors： Franck SE,Korevaar TIM,Petrossians P,Daly AF,Chanson P,Jaffrain-Réa ML,Brue T,Stalla GK,Carvalho D,Colao A,Hána V,Delemer B,Fajardo C,van der Lely AJ,Beckers A,Neggers SJCMM

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...

journal_title：European journal of endocrinology

authors： Romero-Kusabara IL,Filho JV,Scalissi NM,Melo KC,Demartino G,Longui CA,Melo MR,Cury AN

更新日期：2017-04-01 00:00:00

abstract：CONTEXT:The urea cycle is a rate-limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole-body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE:To determin...

journal_title：European journal of endocrinology

authors： Lam T,Poljak A,McLean M,Bahl N,Ho KKY,Birzniece V

更新日期：2017-04-01 00:00:00

abstract：:Approximately 15 million babies are born preterm across the world every year, with less than 37 completed weeks of gestation. Survival rates increased during the last decades with the improvement of neonatal care. With premature birth, babies are deprived of the intense intrauterine growth phase, and postnatal growth ...

journal_title：European journal of endocrinology

authors： Boguszewski MCDS,Cardoso-Demartini AA

更新日期：2017-03-01 00:00:00

abstract：CONTEXT:Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE:To improve the diagnostic accuracy of GH-releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI and sex and established normative data for an automatic immunoassay sp...

journal_title：European journal of endocrinology

authors： Deutschbein T,Bidlingmaier M,Schopohl J,Strasburger CJ,Petersenn S

更新日期：2017-03-01 00:00:00

abstract：:Rituximab (RTX) use in open-label series has been associated with very encouraging responses in patients with active and moderate-to-severe Graves' orbitopathy (GO). Recently, randomized controlled trials of RTX have been performed in such patients to answer the question of clinical efficacy and the safety profile of ...

journal_title：European journal of endocrinology

authors： Stan MN,Salvi M

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Many investigators believe that basal adrenal venous sampling (AVS) should be done simultaneously, whereas others opt for sequential AVS for simplicity and reduced cost. This study aimed to evaluate the concordance of sequential and simultaneous AVS methods. DESIGN AND METHODS:Between 1989 and 2015, bilatera...

journal_title：European journal of endocrinology

authors： Almarzooqi MK,Chagnon M,Soulez G,Giroux MF,Gilbert P,Oliva VL,Perreault P,Bouchard L,Bourdeau I,Lacroix A,Therasse E

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly expressed in brain areas controlling mood and response to stress. Our aims were t...

journal_title：European journal of endocrinology

authors： Valassi E,Crespo I,Keevil BG,Aulinas A,Urgell E,Santos A,Trainer PJ,Webb SM

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Thymic neuroendocrine tumor is the second-most prevalent cause of ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS), which is a rare disease characterized by ectopic ACTH oversecretion from nonpituitary tumors. However, the genetic abnormalities of thymic neuroendocrine tumors with EAS remain largely ...

journal_title：European journal of endocrinology

authors： Li Y,Peng Y,Jiang X,Cheng Y,Zhou W,Su T,Xie J,Zhong X,Song D,Wu L,Fan L,Li M,Hong J,Wang W,Ning G,Cao Y

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options. PURPOSE:We performed a systematic search and meta-analysis to study predictors for relapse after stopping ATD i...

journal_title：European journal of endocrinology

authors： Struja T,Fehlberg H,Kutz A,Guebelin L,Degen C,Mueller B,Schuetz P

更新日期：2017-01-01 00:00:00